Polygonum Cuspidatun Extract

1. Antipyretic and analgesic effects
Resveratrol exerts its therapeutic effects through a variety of different pathways, and has shown some antipyretic and analgesic activity, as shown in studies on intact mice and rats (Lin and Hu, 1987). Its extract has been shown to confer gastric mucosal resistance to stress ulcers caused by suppressed gastric secretion without affecting blood pressure.
2. Anticancer, antimutagenic ability
As an antioxidant, antimutagenic and anti-inflammatory agent, resveratrol has shown chemopreventive properties against cancer. It has also been shown to induce differentiation of human promyelocytic leukemia cells (antiproliferative effect) and inhibit the development of pre-breast cancer lesions in mice. Resveratrol also inhibits protein tyrosine kinase, a substance that catalyzes tyrosine phosphorylation. The kinase is involved in the cytoplasmic signaling of cells that regulate mitosis. The inhibition of protein tyrosine kinase by resveratrol may have an antimutagenic effect by preventing the kinase function.
3. Prevention of heart and liver damage
Resveratrol inhibits the deposition of triglycerides and cholesterol in the liver of mice. It can also increase the levels of aspartate aminotransferase and alanine aminotransferase by inhibiting lipid peroxidation in the liver of mice. Analysis of these two enzymes in serum provides good diagnostic information for heart and liver damage.
4. Antithrombotic function
Resveratrol inhibits the synthesis of lipoxygenase, which is present in white blood cells, heart, brain, lungs and spleen. Therefore, resveratrol can prevent the formation of blood clots in blood vessels. It can also inhibit the aggregation of platelets after treatment with antihypertensive drugs such as clonidine.
5. Enhance the activity of the immune system in wound treatment
Resveratrol can also promote the healing of burns by enhancing the immune system. Luo (1993) studied the efficacy of resveratrol in restoring the suppressed cellular, humoral and nonspecific immune functions of burned mice. Controlled use of resveratrol provides a drug-dependent immunomodulatory effect. Luo et al. (1995) studied mice with different degrees of severe burns and found that resveratrol can restore their damaged functions such as the ability to respond to antigen signals, proliferation, interleukin II synthesis and antibody synthesis through lymphocytes. After the animals with severe burns were treated with controlled resveratrol, their neutrophil levels and neutrophil adhesion rates returned to near normal levels, and their survival time was prolonged.